We can shed much of this needless suffering if we align our rational self with nature, and not strictly oppose or eliminate, but rather transform the feelings and thoughts we have against nature, and accept and see them as they are useful thoughts to us; as they are us. Let me explain.
Since every action is necessary to every other action, this makes anything that happened, is happening, or will happen inevitable.
In light of this, we can see how we needlessly suffer everyday by opposing nature.
If something goes against what we expect, wish, or hope for; if something bad happens; we can no more change it than we can change what we had for breakfast yesterday.
Based on this we should reject the rational part of any feeling against nature:
Reject being against what happened, e.g. depressed about the past.
Reject being against what is right now, e.g. lamenting on your current situation
Rejected being against what could be, e.g. scared of the future.
In a certain respect, each of these reactions (the grief or fear over life past, present or future) is a rejection of life, a degeneration of life, and against our "rational nature" we supposed earlier. If what happens is inevitable, opposing it, or catering a negative reaction from it, is not rational; but perhaps these responses are necessary and impossible to oppose; then it is, by the same logic, irrational and degenerative to oppose them as well.
We can thus stratify two levels of experience. Our initial reaction of desires, emotion, and pre-existing thought, and the second reaction to the relationship this creates; thought moves against thought and our consciousness has a rational reaction, perhaps more evolved or matured than the initial response. It makes sense to recognize these two layers of experience, and not take our first one so seriously; that's why humor was invented: by nature we are quite instinctually and emotionally erratic and irrational, and as such our rational nature evolved the cure of laughter, of joy.
Even though our negative emotions seem like contemptible and painful reactions that cause suffering, this is not giving them proper credit. Such reactions are logically and emotionally necessary, to stimulate further thought and growth; however, we must be strong enough to be inoculated with the negativity of this reaction, and also know what to do with it; the process of transfiguring emotions into thought, and into rational thought (and thus back into a higher, transfigured emotion.)
The connection between our intelligence and emotions seems to have shifted; at first we needed emotions to guide our intelligence in ways that would benefit our survival, and now these tyrannical emotions still gnaw at our thoughts, making "thought" an expression of particular emotions in an irrational way, simply guising itself within intelligence, when really the two are autonomous and distinctly separable. We have our rational self on the one hand, and our emotional self on the other. We experience our emotions through our rational self, thus the perception seems foggy in discerning the two; certainly in retrospect, if we studied each angle we could see that reason is the connections between things, and emotions are the actual things. Thought is non-material, emotions are material; they are feelings. Feelings that tend to guide thoughts. We can reasonably take a step back from irrational thoughts that are spurred by irrational feelings, and yet still be okay to feel our emotions, and even use them to discover new areas of exploration, of weakness that can be turned into strength. In this way they become less contemptible to you, and thus, no suffering.
In a very real way, these negative reactions that oppose nature are what make up our creative, autonomous self. One could hardly call autonomy and creativity negative, but divergent from the norm, perverse, eccentric reactions; in a sense, deviations from life (in our consciousness, in our thoughts against nature) are necessarily our individuality, autonomy, creativity, and thus, very obviously, critical to our growth and progression, and valuable to us in so far as we value our self. We need the negative as much as the positive; beautiful flowers grow out of the most foul manure...
This is hardly an exhaustive rough account of the nature of suffering, but recently I've focused more on our ability to see and distinguish betweens different types of mental suffering, caused by ourselves and our reactions, and how we can lessen this suffering by changing our perspective, our initial attitude, our thoughts about it, our rational reaction, because our general state of mind and state of feeling affects how we think, to what we think, to how we feel. It seems thought and feeling truly are connected; inseparable and connected, yet autonomous.